Description

Testosterone, one of the main sex hormones in the human body, is a steroid hormone with 19 carbon atoms synthesized from cholesterol. About 90% of male testosterone comes from leydig cells, and the rest is produced in adrenal cortex and other tissues; Testosterone in women synthesized by ovarian stromal cells,portal cells and adrenal cortex reticular zone, account for about 50% of total. The remaining 50% is mainly converted from androstenedione in liver, fat, skin and other tissues. It is the precursor of estradiol synthesis in the ovary, and has a certain role in maintaining the female gonadal function. Testosterone exists in blood in two forms: bound and free. The binding state is mainly bound with sex hormone binding protein, albumin and other proteins, accounting for 97%~99%; Free testosterone accounts for 1%~3%, which is the main form of biological activity in vivo. Detection of female testosterone can assist in the diagnosis of polycystic ovary syndrome (PCOS), masculinized tumors in women, congenital adrenal hyperplasia and adrenal tumors. Detection of male testosterone content can assist in the diagnosis of diseases with insufficient testosterone production, such as congenital testicular dysplasia, chromosomal abnormalities, and in addition, it can assist in the diagnosis of hypopituitarism, cirrhosis